Individual alpha frequency proximity associated with repetitive transcranial magnetic stimulation outcome: An independent replication study from the ICON-DB consortium

The aim of the current study was to attempt replicate finding that individual alpha frequency (IAF) as well absolute difference between IAF and 10 Hz stimulation (IAF-prox) is related treatment outcome. Correlations were performed investigate relationship IAF-prox percentage symptom improvement in a sample 153 patients with major depressive disorder treated (N = 59) left dorsolateral prefrontal cortex (DLPFC) or 1 94) right DLPFC repetitive Transcranial Magnetic Stimulation (rTMS). There significant negative correlation only for group. Curve fitting models revealed there quadratic association response group, peak at IAF. main result Corlier colleagues replicated, findings suggest distance may influence clinical outcome non-linear manner. rTMS often administered Hz, which center EEG band. results can make contribution optimizing application rTMS.